Mitomycin-C as a Preventive Measure of Adhesion after Functional Endoscopic Sinus Surgery (FESS)

Document Type : Original Article

Authors

1 Department of ENT, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

2 Drug and Poison Information Center, Pharmacy Department, King Saud University Medical City, Riyadh, Saudi Arabia.

Abstract

Background: Synechia formation in a postoperative nasal cavity is a major factor for suboptimal clinical outcome in functional endoscopic sinus surgery (FESS). Nasal packs medicated with topical agents like mitomycin C have been shown to reduce the formation of synechiae in postoperative patients.
Aim: To assess the role of mitomycin-c (MMC) in preventing synechia formation and ostial stenosis following endoscopic nasal surgery.
Patients and Methods: This is a prospective comparative study performed at the department of Otorhinolaryngology, El-Zhraa University hospital from January 2018 to December 2019 to evaluate the effect of MMC in prevention of nasal adhesions after endoscopic nasal surgery. A total of fifty (50) patients of different age groups and both sexes were involved in the study and divided into two groups, each group include 25 patients, group A with applying MMC and group B without applying MMC.
Results: In the MMC group, there was a reduction of synechia and crustration formation in group A that use MMC than group B without using MMC but with no significance.
Conclusion: Mitomycin C (MMC) is safe and beneficial in decreasing adhesion formation after endoscopic nasal surgery.

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