Elhussieny, F., Saif Eldin, D., Elsharawy, Y. (2020). Mitomycin-C as a Preventive Measure of Adhesion after Functional Endoscopic Sinus Surgery (FESS). Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 21(3), 154-158. doi: 10.21608/ejentas.2020.26708.1189
Fatma Mohamed Elhussieny; Doaa Abd Elhalim Saif Eldin; Yasmin Ahmed Elsharawy. "Mitomycin-C as a Preventive Measure of Adhesion after Functional Endoscopic Sinus Surgery (FESS)". Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 21, 3, 2020, 154-158. doi: 10.21608/ejentas.2020.26708.1189
Elhussieny, F., Saif Eldin, D., Elsharawy, Y. (2020). 'Mitomycin-C as a Preventive Measure of Adhesion after Functional Endoscopic Sinus Surgery (FESS)', Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 21(3), pp. 154-158. doi: 10.21608/ejentas.2020.26708.1189
Elhussieny, F., Saif Eldin, D., Elsharawy, Y. Mitomycin-C as a Preventive Measure of Adhesion after Functional Endoscopic Sinus Surgery (FESS). Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 2020; 21(3): 154-158. doi: 10.21608/ejentas.2020.26708.1189
Mitomycin-C as a Preventive Measure of Adhesion after Functional Endoscopic Sinus Surgery (FESS)
1Department of ENT, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
2Drug and Poison Information Center, Pharmacy Department, King Saud University Medical City, Riyadh, Saudi Arabia.
Abstract
Background: Synechia formation in a postoperative nasal cavity is a major factor for suboptimal clinical outcome in functional endoscopic sinus surgery (FESS). Nasal packs medicated with topical agents like mitomycin C have been shown to reduce the formation of synechiae in postoperative patients. Aim: To assess the role of mitomycin-c (MMC) in preventing synechia formation and ostial stenosis following endoscopic nasal surgery. Patients and Methods: This is a prospective comparative study performed at the department of Otorhinolaryngology, El-Zhraa University hospital from January 2018 to December 2019 to evaluate the effect of MMC in prevention of nasal adhesions after endoscopic nasal surgery. A total of fifty (50) patients of different age groups and both sexes were involved in the study and divided into two groups, each group include 25 patients, group A with applying MMC and group B without applying MMC. Results: In the MMC group, there was a reduction of synechia and crustration formation in group A that use MMC than group B without using MMC but with no significance. Conclusion: Mitomycin C (MMC) is safe and beneficial in decreasing adhesion formation after endoscopic nasal surgery.
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