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Egyptian Journal of Ear, Nose, Throat and Allied Sciences
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CHAVAN, S., MEHERE, Y., KHOND, A., RADHAKRISHNAN, R. (2021). Role of Deferasirox as an Adjuvant to Parenteral Antifungal Therapy in Invasive Fungal Sinusitis. Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 22(22), 1-6. doi: 10.21608/ejentas.2021.70482.1349
SHRINIVAS SHRIPAT CHAVAN; YUGANDHARA DNYANESHWAR MEHERE; ABHISHEK DILIP KHOND; RAHUL RADHAKRISHNAN. "Role of Deferasirox as an Adjuvant to Parenteral Antifungal Therapy in Invasive Fungal Sinusitis". Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 22, 22, 2021, 1-6. doi: 10.21608/ejentas.2021.70482.1349
CHAVAN, S., MEHERE, Y., KHOND, A., RADHAKRISHNAN, R. (2021). 'Role of Deferasirox as an Adjuvant to Parenteral Antifungal Therapy in Invasive Fungal Sinusitis', Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 22(22), pp. 1-6. doi: 10.21608/ejentas.2021.70482.1349
CHAVAN, S., MEHERE, Y., KHOND, A., RADHAKRISHNAN, R. Role of Deferasirox as an Adjuvant to Parenteral Antifungal Therapy in Invasive Fungal Sinusitis. Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 2021; 22(22): 1-6. doi: 10.21608/ejentas.2021.70482.1349

Role of Deferasirox as an Adjuvant to Parenteral Antifungal Therapy in Invasive Fungal Sinusitis

Article 34, Volume 22, Issue 22, 2021, Page 1-6  XML PDF (419.93 K)
Document Type: Original Article
DOI: 10.21608/ejentas.2021.70482.1349
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Authors
SHRINIVAS SHRIPAT CHAVAN1; YUGANDHARA DNYANESHWAR MEHERE1; ABHISHEK DILIP KHOND email orcid 2; RAHUL RADHAKRISHNAN3
1DEPARTMENT OF ENT, GRANT GOVERNEMENT MEDICAL COLLEGE AND SIR J.J. GROUP OF HOSPITALS, BYCULLA ,MUMBAI
2DEPARTMENT OF ENT, GRANT GOVERNEMENT MEDICAL COLLEGE AND SIR J.J. GROUP OF HOSPITALS, BYCULLA ,MUMBAI. MAHARASHTRA UNIVERSITY OF HEALTH SCIENCES, NASHIK, MAHARASHTRA. INDIA
3DEPARTMENT OF GENERAL MEDICINE, GRANT GOVERNMENT MEDICAL COLLEGE AND SIR JJ GROUP OF HOSPITALS,BYCULLA, MUMBAI
Abstract
Background: Invasive Fungal Sinusitis(IFS) is seen in both immunocompromised and immunocompetent patients. All fungi elaborate uptake mechanisms to sequester iron, and produce siderophores with higher affinity for iron. The availability of iron and ability to utilize them are essential for viability and growth of Mucor and Aspergillus. Currently, IFS is dealt with surgical debridement and aggressive medical therapy. Amphotericin B being currently used in medical management. Considering the importance of iron in fungal growth, addition of iron chelating agent as an adjunct has potential beneficial role. The newer iron chelator deferasirox, share higher affinity for iron and hence, deprive the fungi of iron, inhibiting their growth. However, the evidence for deferasirox as adjunct therapy in IFS is limited thus, prompting us for this study.
Aim: To study the role of deferasirox as an adjuvant to parenteral antifungal therapy in invasive fungal sinusitis.
Materials and Methods: A prospective interventional comparative clinical study was conducted. A total of 42 IFS patients were selected for study. About 12 patients were lost due to attrition. Remainder of 30 patients were evenly randomized into Group A and B by chit allocation. After surgical debridement, Patients in group A received only parenteral Amphotericin B and group B received parenteral Amphotericin B and oral deferasirox. The outcomes in two groups were compared clinically,endoscopically and radiologically and analysed using Mann Whitney test.
Conclusion: Parenteral Amphotericin B and deferasirox combination is better than parenteral Amphotericin B alone in treatment of IFS.
Keywords
Amphotericin B; deferasirox; invasive fungal sinusitis; iron chelators
Main Subjects
Otolaryngology including ear, nose and throat diseases
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