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Egyptian Journal of Ear, Nose, Throat and Allied Sciences
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Volume Volume 23 (2022)
Issue Issue 23
Volume Volume 22 (2021)
Volume Volume 21 (2020)
Volume Volume 20 (2019)
Volume Volume 19 (2018)
ZITTOON, R. (2022). Structure and Function Changes of the Organ of Corti After Use of Sildenafil Citrate (VIAGRA®), in Adult Male Guinea Pigs. Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 23(23), 1-6. doi: 10.21608/ejentas.2021.96751.1419
REHAM FAROIK ZITTOON. "Structure and Function Changes of the Organ of Corti After Use of Sildenafil Citrate (VIAGRA®), in Adult Male Guinea Pigs". Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 23, 23, 2022, 1-6. doi: 10.21608/ejentas.2021.96751.1419
ZITTOON, R. (2022). 'Structure and Function Changes of the Organ of Corti After Use of Sildenafil Citrate (VIAGRA®), in Adult Male Guinea Pigs', Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 23(23), pp. 1-6. doi: 10.21608/ejentas.2021.96751.1419
ZITTOON, R. Structure and Function Changes of the Organ of Corti After Use of Sildenafil Citrate (VIAGRA®), in Adult Male Guinea Pigs. Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 2022; 23(23): 1-6. doi: 10.21608/ejentas.2021.96751.1419

Structure and Function Changes of the Organ of Corti After Use of Sildenafil Citrate (VIAGRA®), in Adult Male Guinea Pigs

Article 34, Volume 23, Issue 23, January 2022, Page 1-6  XML PDF (858.31 K)
Document Type: Original Article
DOI: 10.21608/ejentas.2021.96751.1419
Author
REHAM FAROIK ZITTOON email orcid
ENT FACULTY OF MEDICINE SUEZ CANSL UNIVERSITY ISMALLIA
Abstract
Background: Sildenafil citrate has been reported to induce temporary sensorineural hearing loss,tinnitus and dizziness.
Objective: To evaluate the effects of sildenafil citrate on the guinea pigs cochlear structure and function using Otoacoustic
Emissions (OAEs) and light microscopic H & E cochlear sections.
Patients and Methods: This experimental study was conducted on 45 healthy adult male pigmented guinea pigs in
Otolaryngology-Head and neck Surgery and Histology Departments in Suez Canal University, Ismailia-Egypt. Animals
were randomly divided into three groups: Group 1 (n=15): control group. Group 2 (n=15): received the therapeutic dose
of sildenafil citrate. Group 3 (n=15): received double the therapeutic dose of sildenafil citrate.
Results: DPOAEs recorded from the three groups showed that the lowest amplitude was at 1006 kHz (10.4dB) and the
highest at 6060 & 8084 kHz (43.9 & 42.1dB) respectively without statistically significant intergroup difference. In the
H & E cochlear sections, there was disorganization and vacuolation of almost all cells of organ of Corti in group 2 and 3
compared to group 1. Lightly stained cytoplasm, karryorrhectic nuclei and pyknotic ones were also seen. These changes
were more marked in group 3 which showed also some cellular loss in some sections.
Conclusion: Therapeutic dose of sildenafil citrate affects the cellular structure of organ of corti without detectable effects
in DPOAEs.
Keywords
Histology; Inner ear; otoacoustic emissions; sensorineural hearing loss; sildenafil citrate
Main Subjects
Otolaryngology including ear, nose and throat diseases
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