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Egyptian Journal of Ear, Nose, Throat and Allied Sciences
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ZITTOON, R. (2022). Structure and Function Changes of the Organ of Corti After Use of Sildenafil Citrate (VIAGRA®), in Adult Male Guinea Pigs. Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 23(23), 1-6. doi: 10.21608/ejentas.2021.96751.1419
REHAM FAROIK ZITTOON. "Structure and Function Changes of the Organ of Corti After Use of Sildenafil Citrate (VIAGRA®), in Adult Male Guinea Pigs". Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 23, 23, 2022, 1-6. doi: 10.21608/ejentas.2021.96751.1419
ZITTOON, R. (2022). 'Structure and Function Changes of the Organ of Corti After Use of Sildenafil Citrate (VIAGRA®), in Adult Male Guinea Pigs', Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 23(23), pp. 1-6. doi: 10.21608/ejentas.2021.96751.1419
ZITTOON, R. Structure and Function Changes of the Organ of Corti After Use of Sildenafil Citrate (VIAGRA®), in Adult Male Guinea Pigs. Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 2022; 23(23): 1-6. doi: 10.21608/ejentas.2021.96751.1419

Structure and Function Changes of the Organ of Corti After Use of Sildenafil Citrate (VIAGRA®), in Adult Male Guinea Pigs

Article 34, Volume 23, Issue 23, January 2022, Page 1-6  XML PDF (858.31 K)
Document Type: Original Article
DOI: 10.21608/ejentas.2021.96751.1419
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Author
REHAM FAROIK ZITTOON email orcid
ENT FACULTY OF MEDICINE SUEZ CANSL UNIVERSITY ISMALLIA
Abstract
Background: Sildenafil citrate has been reported to induce temporary sensorineural hearing loss,tinnitus and dizziness.
Objective: To evaluate the effects of sildenafil citrate on the guinea pigs cochlear structure and function using Otoacoustic
Emissions (OAEs) and light microscopic H & E cochlear sections.
Patients and Methods: This experimental study was conducted on 45 healthy adult male pigmented guinea pigs in
Otolaryngology-Head and neck Surgery and Histology Departments in Suez Canal University, Ismailia-Egypt. Animals
were randomly divided into three groups: Group 1 (n=15): control group. Group 2 (n=15): received the therapeutic dose
of sildenafil citrate. Group 3 (n=15): received double the therapeutic dose of sildenafil citrate.
Results: DPOAEs recorded from the three groups showed that the lowest amplitude was at 1006 kHz (10.4dB) and the
highest at 6060 & 8084 kHz (43.9 & 42.1dB) respectively without statistically significant intergroup difference. In the
H & E cochlear sections, there was disorganization and vacuolation of almost all cells of organ of Corti in group 2 and 3
compared to group 1. Lightly stained cytoplasm, karryorrhectic nuclei and pyknotic ones were also seen. These changes
were more marked in group 3 which showed also some cellular loss in some sections.
Conclusion: Therapeutic dose of sildenafil citrate affects the cellular structure of organ of corti without detectable effects
in DPOAEs.
Keywords
Histology; Inner ear; otoacoustic emissions; sensorineural hearing loss; sildenafil citrate
Main Subjects
Otolaryngology including ear, nose and throat diseases
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