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Egyptian Journal of Ear, Nose, Throat and Allied Sciences
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Ghandour, H., Metyas, M., samy, A. (2025). Screening of Vitamin B12 in Children Diagnosed as Autism Spectrum Disorder. Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 26(26), 1-17. doi: 10.21608/ejentas.2025.358505.1819
Hassan Hosny Ghandour; Martha Metyas; azza samy. "Screening of Vitamin B12 in Children Diagnosed as Autism Spectrum Disorder". Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 26, 26, 2025, 1-17. doi: 10.21608/ejentas.2025.358505.1819
Ghandour, H., Metyas, M., samy, A. (2025). 'Screening of Vitamin B12 in Children Diagnosed as Autism Spectrum Disorder', Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 26(26), pp. 1-17. doi: 10.21608/ejentas.2025.358505.1819
Ghandour, H., Metyas, M., samy, A. Screening of Vitamin B12 in Children Diagnosed as Autism Spectrum Disorder. Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 2025; 26(26): 1-17. doi: 10.21608/ejentas.2025.358505.1819

Screening of Vitamin B12 in Children Diagnosed as Autism Spectrum Disorder

Article 14, Volume 26, Issue 26, 2025, Page 1-17  XML PDF (462.3 K)
Document Type: Original Article
DOI: 10.21608/ejentas.2025.358505.1819
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Authors
Hassan Hosny Ghandour1; Martha Metyas2; azza samy email 3
1Phoniatric Unit, Otorhinolaryngology-Head and Neck Surgery Department, Faculty of Medicine, Ain Shams University, Egypt
2Phoniatric Specialist
3Assistant professor at phoniatric department at hearing and speech institute
Abstract
Background: A deficiency in Vitamin B12 leads to megaloblastic anemia and neurological disorders. In children with Autism Spectrum Disorder (ASD), gastrointestinal issues can impair the absorption of certain vitamins, including Vitamin B12, resulting in its deficiency.
Aim: This study aims to assess Vitamin B12 levels in children with ASD to identify potential etiological factors and explore their role in management if confirmed.
Patients and Methods: A case-control study was conducted involving 30 children diagnosed with Autism Spectrum Disorder (ASD) and 30 neurotypical children serving as a control group, all aged 3 - 8 years. All participants underwent the Modified Arabic Preschool Language Scale (PLS-4), the Stanford-Binet Intelligence Scales, Fifth Edition, and the Childhood Autism Rating Scale (CARS).
Results: Children with ASD had notably lower levels of Vitamin B12 than the control group.
Conclusion: The study found that children with ASD had lower Vitamin B12 levels compared to the control group and exhibited a reduced overall language level.
Keywords
Arabic PLS-4; autism spectrum disorder; CARS; language delay; vitamin B12
Main Subjects
Phoniatric Sciences and medicine as a subpecialty of ENT
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