Injection of Platelet-Rich Plasma in patients with Atrophic Vocal Folds

Articles in Press

Document Type : Original Article

Authors

1 Otolaryngology Department, Kasr Al-Aini, Faculty of Medicine, Cairo University, EGYPT.

2 Otolaryngology Department, Kasr Al-Aini, Faculty of Medicine, Cairo University, EGYPT

3 ENT department, kasr alaini hospital, Cairo University

4 Otolaryngology department faculty of medicine Cairo university

Abstract

Background: To verify the effectiveness of platelet-rich plasma (PRP) injection on voice quality in patients with glottic insufficiency. A prospective study was conducted on 20 adult patients of both genders aged above 20 years old with glottic insufficiency candidate for (PRP) injection into vocal fold using fiber-optic laryngoscope under local anesthesia.
Results: No significant improvement was found between fundamental frequency, jitter %, noise to harmonic ratio and maximum phonation time among pre-injection, after month and after 3 months but shimmer % showed a statistically significant decrease after 3 months of follow-up from pre-injection while 1 month showed no statistically significant difference from pre-injection.
Conclusion: (PRP) is safe to use as an option for treatment of glottic insufficiency . The risk-benefit ratio makes even small or partial gains advantageous. Significant decrease in shimmer% was observed after 3 months following PRP injection. Additionally, other acoustic parameters were improved after one month and 3 months of follow-up but with no statistically significant differences compared with the baseline before the injection.
Keywords: Platelet-rich plasma, vocal fold atrophy, voice analysis.

Keywords

Main Subjects

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

Articles in Press, Accepted Manuscript
Available Online from 04 August 2025

Files

Share

How to cite

Statistics