Hassan, M., Emam, A., Radwan, A., Abdelhameed, A., Salah Eldin, S., Mohamed, M. (2021). Is Deficiency of 25-Hydroxy Vitamin D A Risk Factor for Autism? A Preliminary Study. Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 22(22), 1-9. doi: 10.21608/ejentas.2021.44200.1264
Megahed Mohamed Hassan; Ahmed Aboud Emam; Ashraf Radwan; Amany Abdelhameed; Sameh Salah Eldin; Montasser Mohamed. "Is Deficiency of 25-Hydroxy Vitamin D A Risk Factor for Autism? A Preliminary Study". Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 22, 22, 2021, 1-9. doi: 10.21608/ejentas.2021.44200.1264
Hassan, M., Emam, A., Radwan, A., Abdelhameed, A., Salah Eldin, S., Mohamed, M. (2021). 'Is Deficiency of 25-Hydroxy Vitamin D A Risk Factor for Autism? A Preliminary Study', Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 22(22), pp. 1-9. doi: 10.21608/ejentas.2021.44200.1264
Hassan, M., Emam, A., Radwan, A., Abdelhameed, A., Salah Eldin, S., Mohamed, M. Is Deficiency of 25-Hydroxy Vitamin D A Risk Factor for Autism? A Preliminary Study. Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 2021; 22(22): 1-9. doi: 10.21608/ejentas.2021.44200.1264
Is Deficiency of 25-Hydroxy Vitamin D A Risk Factor for Autism? A Preliminary Study
1Phoniatrics Unit, Otolaryngology, Faculty of Medicine, Sohag University, Sohag, Egypt
2Pediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt
3Physiology, Faculty of Medicine, Sohag University, Sohag, Egypt
4Medical Biochemistry, Faculty of Medicine, Assuit AlAzhar University, Assuit, Egypt
Abstract
Objective: To investigate the status of 25-hydroxy-vitamin-D [25-(OH)-D] in autistic children and to correlate with their mothers vitamin statuses and autism severity. Methods: In this case-control study, serum 25(OH)-D was measured in autistic children and controls (n=36 each) and in mothers of autistics and control mothers (n=24 each). Comparison and correlation studies were performed. Results: Both autistic children and their mothers have lower 25-(OH)-D compared to their controls with significant differences (PConclusion: Deficiency of 25(OH)-D is common in autistic children and related to the severity of symptoms. Vitamin D deficiency in children might be maternal-dependent. Deficiency of 25(OH)-D in autistic children and their mothers could be the primary predisposing factor for autism. This may find a common link among the genetic, immunological, anatomical, biochemical and physiological factors putting the puzzles together. Early supplementation of vitamin D could improve autistic manifestations.
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