Histopathological Effects of Cytarabine on Rabbit Tongue Tissue and the Possibility of Treatment with Vitamin E.

Document Type : Original Article

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Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Al-Farahidi University, Baghdad, Iraq.

Abstract

Introduction: This study aimed to investigate the possibility of treating the side effects of cytarabine on the tongue using
vitamin E in rabbits.
Material and Methods: Three-month-old rabbits weighing 1.5 to 2.0 kg were utilized in this investigation. A total of 18
rabbits were separated into 3 equal groups at random, with each group containing 6 rabbits. Vitamin E was administered
orally, and cytarabine was administered intraperitoneally. Each treatment was administered daily for one week, following
groups distilled water was administered parenterally to a control group, and A 50 mg/kg dosage of cytarabine was
administered to the second group. The third group was given cytarabine 50 mg/kg, and then 5 hours later, it was given
vitamin E at a dose of 800 IU.
Results: The result revealed The tongue Cytarabine treated group showed hyperkeratosis with hyalinization, ballooning
degeneration, necrosis of the epithelial cells degeneration, (Zenker's) of skeletal muscle cells with atrophy, oedema
between it, inflammation, and congestion of blood vessels, while the Cytarabine with vitamin E treated group showing
intact mucosa with filiform and epithelial cells, and longitudinal and transverse skeletal muscles, also showing mild
hyperkeratosis, and degeneration of the epithelial cells and intact fungiform papillae.
Conclusions: The conclusion from this study is that vitamin E is a promising treatment for cytarabine's side effects and
that combining them has positive effects on treating rabbits' tongue lesions.

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