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Maharani, I., Christianty, F., Handoko, E., Setijowati, N. (2023). Endotype Conformity with Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) Score in Chronic Rhinosinusitis. Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 24(24), 1-7. doi: 10.21608/ejentas.2023.185570.1600
Iriana Maharani; Finna Christianty; Edi Handoko; Nanik Setijowati. "Endotype Conformity with Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) Score in Chronic Rhinosinusitis". Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 24, 24, 2023, 1-7. doi: 10.21608/ejentas.2023.185570.1600
Maharani, I., Christianty, F., Handoko, E., Setijowati, N. (2023). 'Endotype Conformity with Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) Score in Chronic Rhinosinusitis', Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 24(24), pp. 1-7. doi: 10.21608/ejentas.2023.185570.1600
Maharani, I., Christianty, F., Handoko, E., Setijowati, N. Endotype Conformity with Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) Score in Chronic Rhinosinusitis. Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 2023; 24(24): 1-7. doi: 10.21608/ejentas.2023.185570.1600

Endotype Conformity with Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) Score in Chronic Rhinosinusitis

Article 48, Volume 24, Issue 24, 2023, Page 1-7  XML PDF (376.03 K)
Document Type: Original Article
DOI: 10.21608/ejentas.2023.185570.1600
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Authors
Iriana Maharani1; Finna Christianty email 2; Edi Handoko3; Nanik Setijowati4
1Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Brawijaya University/RSUD Dr. Saiful Anwar, Malang, Indonesia
2Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Brawijaya University /Dr. Saiful Anwar General Hospital, Malang, Indonesia
3Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Brawijaya University/Dr. Saiful Anwar General Hospital, Malang, Indonesia
4Department of Public Health, Faculty of Medicine, Brawijaya University
Abstract
Introduction: Chronic rhinosinusitis (CRS) is one of the most prevalent disease entities in ORL-HNS field. Management strategy of CRS remains challenging among otorhinolaryngologist. Currently, CRS was known as a heterogeneous disease with various endotypes and phenotypes. By identifying endotypes, comprehensive management strategy in CRS was expected. The Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) score was a categorical score developed from Japan to diagnose eosinophilic chronic rhinosinusitis (eCRS) and non-eosinophilic chronic rhinosinusitis (non-eCRS). The assessment of JESREC score was expected to have conformity with CRS endotypes so that it can be used as future efficient diagnostic modality.
Objective: This study aims to determine conformity and accuracy of endotype with JESREC score.
Patients and Methods: An analytic study with a cross-sectional design involving 33 samples of primary CRS. Biomarker for specific endotypes measured by ELISA.
Results: Statistical analysis with Mc. Nemar showed no difference/ a conformity between JESREC score and CRS endotypes (p>0.05) with sensitivity 61,5% and specificity 90%.
Conclusion: JESREC score is considered a screening modality for CRS endotype
Keywords
Chronic rhinosinusitis; endotype; JESREC; phenotype
Main Subjects
Otolaryngology including ear, nose and throat diseases
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