Endotype Conformity with Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) Score in Chronic Rhinosinusitis

Document Type : Original Article

Authors

1 Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Brawijaya University/RSUD Dr. Saiful Anwar, Malang, Indonesia

2 Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Brawijaya University /Dr. Saiful Anwar General Hospital, Malang, Indonesia

3 Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Brawijaya University/Dr. Saiful Anwar General Hospital, Malang, Indonesia

4 Department of Public Health, Faculty of Medicine, Brawijaya University

Abstract

Introduction: Chronic rhinosinusitis (CRS) is one of the most prevalent disease entities in ORL-HNS field. Management strategy of CRS remains challenging among otorhinolaryngologist. Currently, CRS was known as a heterogeneous disease with various endotypes and phenotypes. By identifying endotypes, comprehensive management strategy in CRS was expected. The Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) score was a categorical score developed from Japan to diagnose eosinophilic chronic rhinosinusitis (eCRS) and non-eosinophilic chronic rhinosinusitis (non-eCRS). The assessment of JESREC score was expected to have conformity with CRS endotypes so that it can be used as future efficient diagnostic modality.
Objective: This study aims to determine conformity and accuracy of endotype with JESREC score.
Patients and Methods: An analytic study with a cross-sectional design involving 33 samples of primary CRS. Biomarker for specific endotypes measured by ELISA.
Results: Statistical analysis with Mc. Nemar showed no difference/ a conformity between JESREC score and CRS endotypes (p>0.05) with sensitivity 61,5% and specificity 90%.
Conclusion: JESREC score is considered a screening modality for CRS endotype

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