abdelrahman, T., hassanein, K., helmy, M., Amer, I., mahmoud, A., aldarder, A., eid, R., Ahmed, A. (2024). Parathyroid Carcinoma and Recurrent Hyperparathyroidm: Challenges and Management Options. Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 25(25), 1-7. doi: 10.21608/ejentas.2022.174289.1577
tarek elsayed ftohy abdelrahman; kamal a hassanein; mina zarif helmy; Islam Amer; ahmed gaber mahmoud; ahmed abdelkahar aldarder; rasha M eid; Ahmed roshdi hamed Ahmed. "Parathyroid Carcinoma and Recurrent Hyperparathyroidm: Challenges and Management Options". Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 25, 25, 2024, 1-7. doi: 10.21608/ejentas.2022.174289.1577
abdelrahman, T., hassanein, K., helmy, M., Amer, I., mahmoud, A., aldarder, A., eid, R., Ahmed, A. (2024). 'Parathyroid Carcinoma and Recurrent Hyperparathyroidm: Challenges and Management Options', Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 25(25), pp. 1-7. doi: 10.21608/ejentas.2022.174289.1577
abdelrahman, T., hassanein, K., helmy, M., Amer, I., mahmoud, A., aldarder, A., eid, R., Ahmed, A. Parathyroid Carcinoma and Recurrent Hyperparathyroidm: Challenges and Management Options. Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 2024; 25(25): 1-7. doi: 10.21608/ejentas.2022.174289.1577
Parathyroid Carcinoma and Recurrent Hyperparathyroidm: Challenges and Management Options
1head and neck surgery unit , department of surgery, sohag faculty of medicine, sohag , egypt
2professor of Head and Neck Surgery, sohag-faculty of medicine - surgery department
3assistant professor of surgery , surgery department , sohag university
4maxillofacial, head and neck surgery unit, General surgery department ,Faculty of Medicine ,Sohag University
5department of surgery, faculty of medicine , sohag university
6assistant professor of surgery , department of surgery, sohag faculty of medicine, sohag , egypt
7clinical pathology department, sohag general hospital
8Pathology department; Faculty of Medicine, Sohag University; Egypt
Abstract
Introduction: Parathyroid carcinoma is very rare, but it is resembling important cause of recurrent hyperparathyroidism. Till now no clear guidelines for treatment of parathyroid carcinoma and its associated conditions including hyperparathyroidism. The aim of the study to evaluate the incidence and management modalities of such challenging cases. Material and Methods: Retrospective study for 129 patients diagnosed as primary hyperparathyroidism From march 2012 to June 2020,. Recurrent hyperparathyroidism developed in 7 cases 6 patients of them due to parathyroid carcinoma .medical records and patients characteristics and pathological evaluation and treatment modalities were reviewed. Results: Parathyroid carcinoma diagnosed in 6 patients (4.6%):, 4 males and 2 females with a mean age of years (61.5) range 54–72 years. The mean serum calcium at the initial diagnosis of parathyroid carcinoma cases was 12.73 mg/dL (10.8.–14.2 mg/dL). Elevated serum parathormone were noted in all patients preoperatively, with a mean of 1691.5 pg/mL (630 –3366 pg/ mL). parathyroidectomy done in 5 patients and en block resection in one case in the initial operation, all cases developed recurrence of manifestation from (7 month-26 months) , reoperation needed for all cases and one case needed radiotherapy. Conclusion: Parathyroid carcinoma is very challenging disease with high rate of recurrence, multidisciplinary approach including surgery, medical treatment for hypercalcemia is needed to improve patients outcome .
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